KIVO Med
Krebs cycle: oxidising acetyl-CoA and regenerating oxaloacetate
The citric acid cycle links aerobic acetyl-CoA oxidation to production of reduced coenzymes and biosynthetic intermediates.
- 44 explained questions
- 22 flashcards
- 124 estimated course minutes
Updated
What you will learn
- Locate the cycle, its substrates and its products in the cell.
- Follow its eight reactions and identify their yields of reduced coenzymes or GTP.
- Explain its regulation, amphibolic role and conventional energy yield.
Course outline
A mitochondrial cycle at the crossroads of fuels
The cycle receives acetyl-CoA, captures energy from its oxidation, and supplies biosynthetic intermediates.
14 min
Move pyruvate in and form acetyl-CoA
Pyruvate successively crosses both mitochondrial membranes before irreversible conversion into acetyl-CoA.
12 min
Condensation, isomerization, and two decarboxylations
The first four reactions bring in acetyl, prepare its oxidation, and lead to succinyl-CoA with two NADH,H+ and two CO2.
24 min
Recover energy and regenerate oxaloacetate
The final four reactions convert succinyl-CoA into oxaloacetate while forming GTP, FADH2, and NADH,H+.
22 min
Adjust flux and replace intermediates
The cycle responds to energy status, supplies synthetic precursors, and must replace every withdrawn intermediate.
28 min
Count energy and transfer reducing power
One turn yields three NADH,H+, one FADH2, and one GTP; whole-glucose yield then depends on the cytosolic shuttle.
24 min
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