KIVO Med
Fatty-acid metabolism: synthesis and degradation
Connect the roles of fatty acids with lipogenesis, β-oxidation, and the fate of acetyl-CoA.
- 40 explained questions
- 36 flashcards
- 287 estimated course minutes
Updated
What you will learn
- Describe the structural, functional, and energetic roles of fatty acids.
- Explain the citrate shuttle, the Wakil pathway, and the palmitate-synthesis balance.
- Describe activation, the carnitine shuttle, and the four reactions of β-oxidation.
- Calculate the energy balances given by the course and distinguish even, odd, and unsaturated chains.
- Relate ACC and CAT I regulation to nutritional state and acetyl-CoA fate.
Course outline
Fatty acids, between construction and energy production
Locate the roles of fatty acids and understand how lipogenesis and β-oxidation organize two opposing metabolic directions.
18 min
Preparing lipogenesis and exporting acetyl-CoA
Identify the tissues and requirements of synthesis, then follow the reactions that indirectly transfer mitochondrial acetyl-CoA into the cytosol.
36 min
Committing the Wakil pathway and understanding fatty acid synthase
Form malonyl-CoA through ACC, then identify the activities and two thiols that organize chain assembly.
32 min
Building palmitate, one reaction at a time
Follow the four repeated FAS reactions separately, then count the turns, carbons and coenzymes consumed.
38 min
Modifying palmitate: elongation and desaturation
Lengthen the C16 chain, introduce a Δ9 double bond and understand why some fatty acids must come from food.
28 min
Regulating lipogenesis according to energy state
Read the covalent, hormonal and allosteric controls of ACC, the rate-limiting synthesis enzyme, separately.
25 min
Activating fatty acid and crossing the mitochondrial membrane
Locate β-oxidation, pay the activation cost, then follow every step of the carnitine shuttle.
30 min
One β-oxidation turn and its yield
Study the four matrix reactions separately, then establish the balance of one turn and of palmitate.
36 min
Odd chains, unsaturation and metabolic direction
Adapt β-oxidation to odd or unsaturated chains, understand its control by CAT I and follow the resulting acetyl-CoA.
44 min
Study and practise with KIVO Med
This preview shows the available content. Full courses, explanations and flashcards are available in the app with an account and access to the relevant programme. Prices and access terms are shown there.
Educational resources for medical studies; they do not replace your faculty’s teaching or medical advice.
In the same subject
Lipids: general principles and classification
Define lipids through their properties, functions, and transport, then organise their principal structural families.
Fatty acids: structure and properties
Definition, nomenclature, families, atypical fatty acids, eicosanoids and physicochemical properties.
Simple lipids: structure and properties
Glycerides, cerides and sterides: structures, nomenclature, storage, reactions and biological roles.
Complex lipids: structure and properties
Glycerophospholipids, sphingolipids, amphiphilicity, hydrolysis and membrane, signalling and recognition roles.