KIVO Med
Triacylglycerol metabolism
Digestion, transport, storage, lipolysis, biosynthesis and hormonal regulation of triacylglycerols.
- 25 explained questions
- 24 flashcards
- 195 estimated course minutes
Updated
What you will learn
- Describe triacylglycerol handling in intestine, blood, adipose tissue, liver and consuming tissues.
- Link enzymes and cofactors to lipolysis and biosynthetic pathways.
- Predict pathway direction from nutritional, energetic and hormonal state.
Course outline
Building, transporting or mobilising triglycerides
Triglyceride metabolism connects dietary lipids, adipocyte stores and energy supplied to tissues.
12 min
Organs and flow direction
Intestine, liver, adipose tissue and consuming tissues give triglycerides distinct origins and destinations.
22 min
Digestive lipolysis: producing absorbable 2-monoglyceride
Emulsification exposes triglycerides; lipases rapidly release chains 1 and 3 and more slowly chain 2.
30 min
Intravascular and adipocyte lipolysis
LPL removes lipoprotein TG, hepatic lipase remodels IDL/HDL and HSL mobilises the cellular store.
28 min
The intestinal 2-monoacylglycerol pathway
The enterocyte activates fatty acids, then adds two acyl groups to 2-MAG to rebuild an exogenous triglyceride.
22 min
The glycerol-3-phosphate and phosphatidic acid pathway
Liver, adipocytes and muscles build triglycerides from glycerol-3-phosphate through phosphatidic acid and then diacylglycerol.
28 min
Hormonal regulation of adipocyte lipolysis
Hormones switch hormone-sensitive lipase between an active phosphorylated form and an inactive dephosphorylated form.
26 min
Nutritional state and integration of flows
After a meal, during fasting and during exercise, the adipocyte reverses its priorities between storage and mobilization.
27 min
Study and practise with KIVO Med
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Educational resources for medical studies; they do not replace your faculty’s teaching or medical advice.
In the same subject
Lipids: general principles and classification
Define lipids through their properties, functions, and transport, then organise their principal structural families.
Fatty acids: structure and properties
Definition, nomenclature, families, atypical fatty acids, eicosanoids and physicochemical properties.
Simple lipids: structure and properties
Glycerides, cerides and sterides: structures, nomenclature, storage, reactions and biological roles.
Complex lipids: structure and properties
Glycerophospholipids, sphingolipids, amphiphilicity, hydrolysis and membrane, signalling and recognition roles.